HDAC6/8/BRPF1-IN-1 is a dual inhibitor of both HDAC6/8 and the bromodomain and PHD finger containing protein 1 (BRPF1) . HDAC6/8/BRPF1-IN-1 has inhibitory activity for HDAC1 , HDAC6 and HDAC8 with IC 50 values of 797 nM, 344 nM and 908 nM, respectively. HDAC6/8/BRPF1-IN-1 has inhibitory activity for BRPF1 with an K d value of 175.2 nM. HDAC6/8/BRPF1-IN-1 can be used for the research of cancer .
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