HDAC-IN-47

Overview

HDAC-IN-47 is an orally active inhibitor of histone deacetylase ( HDAC ), with IC 50 s of 19.75 nM ( HDAC1 ), 5.63 nM ( HDAC2 ), 40.27 nM ( HDAC3 ), 57.8 nM ( HDAC2 ), 302.73 nM ( HDAC8 ), respectively. HDAC-IN-47 inhibits autophagy and induces apoptosis via the Bax/Bcl-2 and caspase-3 pathways. HDAC-IN-47 arrests cell cycle at G2/M phase, and shows anti-tumor efficacy in vivo.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > HDAC

Product Information

• Catalog No.: HY-151443
• CAS No.: 3033608-94-2
• Molecular Formula: C17H20BrN3O4
• Molecular Weight: 410.26
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source