JNK3 inhibitor-5 (Compound 22b) is a potent and selective JNK3 inhibitor with an IC 50 of 0.379 nM. JNK3 inhibitor-5 effectively protects the neuronal cells against amyloid beta-induced apoptosis . JNK3 inhibitor-5 has a high cell permeability and is predicted as BBB permeable.
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