LWG-301 is an allosteric inhibitor of Glutaminase 1 ( GLS1 ) with an IC 50 value of 7 nM. LWG-301 significantly block glutamine metabolism, increases intracellular ROS , thus induces apoptosis . LWG-301 exhibits moderate antitumor effects in HCT116 xenograft model.
Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Glutaminase | Products > Signaling Pathways > Apoptosis
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