PARL-IN-1 is a potent PARL inhibitor with an IC 50 value of 28 nM. PARL-IN-1 inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 promotes PINK1/Parkin-dependent mitophagy .
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Autophagy | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > PINK1/Parkin | Products > Signaling Pathways > Mitophagy
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