JMJD3/HDAC-IN-1

Overview

JMJD3/HDAC-IN-1 (compound A5b) is a dual inhibitor targeting Jumonji domain-containing protein demethylase 3 (JMJD3) and histone deacetylase ( HDAC1 , IC 50 =16 nM). JMJD3/HDAC-IN-1 promotes hypermethylation of histone H3K27 and hyperacetylation of H3K9, and also cleaves caspase-7 and PARP to induce apoptosis . JMJD3/HDAC-IN-1 effectively inhibits cancer cell cloning, migration, and invasion.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Histone Demethylase

Product Information

• Catalog No.: HY-156094
• CAS No.: 2883046-06-6
• Molecular Formula: C21H30N6O2
• Molecular Weight: 398.50
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source