mHTT-IN-2

Overview

mHTT-IN-2 (compound 27) is a potent inhibitor ( EC 50 =0.066 μM) of mutant huntingtin (mHTT). mHTT-IN-2 reduces canonical splicing of HTT RNA exons [49-50] and is a splicing regulator of the huntingtin (HTT) gene. mHTT-IN-2 exhibits inhibitory activity in vitro and in vivo in human HD stem cells and mouse BACHD models. mHTT-IN-2 may be used in the study of branaplam-related peripheral neuropathy.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Huntingtin

Product Information

• Catalog No.: HY-156103
• CAS No.: 2743336-70-9
• Molecular Formula: C20H22FN7O
• Molecular Weight: 395.43
• Purity: 99.35%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.32 mM); Clear solution
• Availability: In-stock

Source

Original product source