Votoplam

Overview

Votoplam (PTC518) is a blood-brain barrier-permeable HTT pre-mRNA inhibitor with an IC 50 ≤ 0.1 μM. Votoplam modulates the splicing process of HTT pre-mRNA to include a pseudo-exon carrying a premature translation termination codon, thereby triggering HTT mRNA degradation. Votoplam is applicable to research related to Huntington's disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Huntington's Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Huntingtin

Product Information

• Catalog No.: HY-156650
• CAS No.: 2407849-89-0
• Molecular Formula: C21H25N9O
• Molecular Weight: 419.48
• Purity: 99.51%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1.25 mg/mL (2.98 mM); Clear solution
• Availability: In-stock

Source

Original product source