Erastin

Overview

Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels ( VDAC2/VDAC3 ) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species . Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > VDAC | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Disulfidptosis

Product Information

• Catalog No.: HY-15763
• CAS No.: 571203-78-6
• Molecular Formula: C30H31ClN4O4
• Molecular Weight: 547.04
• Purity: 99.91%
• Storage: Powder -20°C, 3 years , 4°C, 2 years * The compound is unstable in solutions, freshly prepared is recommended.
• Solubility: ≥ 1.25 mg/mL (2.29 mM); Clear solution
• Availability: In-stock

Source

Original product source