CVN293 is a selective and brain permeable potassium ion (K + ) channel KCNK13 inhibtor with IC 50 s of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively. CVN293 potently inhibits the NLRP3-inflammasome mediated production of the proinflammatory cytokine IL-1β in microglia.
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