HRS-4642

Overview

HRS-4642 is a high affinity, selective, long-acting, and non-covalent KRAS G12D inhibitor with a K d value of 0.083 nM. HRS-4642 inhibits the binding of KRAS G12D to SOS1 or RAF1, thereby blocking the downstream MEK - ERK signaling pathway. HRS-4642 promotes Apoptosis . HRS-4642 alone or combined with Carfilzomib ( HY-10455 ) effectively shapes the tumor microenvironment. HRS-4642 has an anti-cancer effect on pancreatic and colorectal cancers carrying the KRAS G12D mutation[1] [2][3] .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Pancreatic Cancer | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Ras | Products > Signaling Pathways > MEK | Products > Signaling Pathways > PERK | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-159127
• CAS No.: 2836263-09-1
• Molecular Formula: C34H35F3N6O3
• Molecular Weight: 632.68
• Purity: 99.74%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (7.90 mM); Clear solution
• Availability: In-stock

Source

Original product source