Claziprotamidum

Overview

Claziprotamidum (Claziprotamide; BBP-671) is a panthothenate kinase ( PANK ) activator with oral activity and blood-brain barrier permeability. Claziprotamidum binds to and activates all PANK isoforms, with the highest affinity for PANK3 ( K D = 97 pM; IC 50 = 1.39 nM). Claziprotamidum increases the intracellular biosynthesis of Coenzyme A ( HY-128851 ) and restores mitochondrial function. Claziprotamidum can be used in the research of pantothenate kinase-associated neurodegeneration and propionic acidemia.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > PANK

Product Information

• Catalog No.: HY-159509
• CAS No.: 2361124-03-8
• Molecular Formula: C19H20ClFN4O
• Molecular Weight: 374.84
• Purity: 98.33%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (13.34 mM); Suspended solution
• Availability: In-stock

Source

Original product source