CS4 is a selective HDAC inhibitor with the IC 50 values of 38 nM, 12 nM, 5.8 μM, 19 μM and 61 μM against of HDAC1 , HDAC6 , HDAC8 , HDAC4 and HDAC11 , respectively. CS4 promotes α-tubulin and histone 3 acetylation. CS4 activates PPARγ and blocks glycolysis . CS4 induces cell cycle arrest at G2 phase and apoptosis , and shows anticancer effect both in vivo and in vitro .
Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > PPAR | Products > Signaling Pathways > Apoptosis
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