PLK1/BRD4-IN-2 (compound 15) is a BI-2536 ( HY-50698 ) analog and dual inhibitor that targets both Polo-like kinase 1 ( PLK1 ) and BRD4 bromodomain (BRD4-BD1 IC 50 =28 nM, PLK1 IC 50 =40 nM).
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