GDC-3280 (AK3287; AKEX0011) is an orally active compound based on Pirfenidone ( HY-B0673 )'s phenyl pyridone scaffold. GDC-3280 alleviates the inflammatory and fibrotic reaction of silicosis by inhibiting the ASK1-p38 MAPK pathway and regulating macrophage polarization. GDC-3280 exhibits anti-inflammatory and anti-fibrotic effects.
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