PHGDH-IN-5

Overview

PHGDH-IN-5 (Compound B12) is a covalen inhibitor of PHGDH with an IC 50 value of 0.29 μM. PHGDH-IN-5 can inhibit cell proliferation in cancer cell lines overexpressing PHGDH . PHGDH-IN-5 can reduce the production of serine derived from glucose in MDA-MB-468 cells.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Phosphoglycerate Dehydrogenase (PHGDH)

Product Information

• Catalog No.: HY-161456
• CAS No.: 17402-86-7
• Molecular Formula: C8H5NO4S
• Molecular Weight: 211.19
• Purity: 98.12%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (23.68 mM); Clear solution
• Availability: In-stock

Source

Original product source