Cysmethynil is an Icmt inhibitor( IC 50 = 2.4 μM). Cysmethynil inhibites RAS membrane binding and EGF signal transduction. Cysmethynil prevents the cells in the G1 phase and induces autophagy . Cysmethynil inhibits PC3 cells proliferation, has synergistic effect with Paclitaxel ( HY-B0015 ) and Doxorubicin ( HY-15142A ). Cysmethynil has anti-tumor effects and can be used for solid tumor (such as prostate cancer et al.) research.
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