SL44

Overview

SL44 is an agonist for human caseinolytic protease P ( HsClpP ), with an EC 50 of 1.30 μM. SL44 inhibits the proliferation of LM3 with an IC 50 of 3.1 μM. SL44 induces apoptosis in HCC cells, through the degradation of respiratory chain complex subunits. SL44 exhibits antitumor efficacy in mouse models without obvious toxicity (LD 50 =400 mg/kg). SL44 exhibits good pharmacokinetic characters in rat models.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > ClpP

Product Information

• Catalog No.: HY-162650
• CAS No.: 3054715-45-3
• Molecular Formula: C22H20ClFN4O
• Molecular Weight: 410.87
• Purity: 99.57%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source