EPZ033294

CAS No.：1887195-17-6
Grade：98.41%
Formula：C20H22ClN7O
M.W.：411.89
Solvent：≥ 2.5 mg/mL (6.07 mM); Clear solution

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

EPZ033294 is an inhibitor of SYMD2 ( IC 50 is 3.9 nM). SYMD2 itself has catalytic activity and can methylate the lysine residue of BTF3 to BTF3me1, which was experimentally demonstrated by detecting an IC 50 of 2.9 nM for inhibition of BTF3ME1 by SYMD2 , indicating an active inhibition of SYMD2 by EPZ033294. EPZ033294 (0-50 µM) has an inhibitory effect on SYMD2 and a concentration-dependent inhibitory effect in 293T.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Histone Methyltransferase

Product Information

Catalog No.: HY-164144
CAS No.: 1887195-17-6
Molecular Formula: C20H22ClN7O
Molecular Weight: 411.89
Purity: 98.41%
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Solubility: ≥ 2.5 mg/mL (6.07 mM); Clear solution
Availability: In-stock

Source

Original product source

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