SST0116CL1 free base

Overview

SST0116CL1 free base is a HSP90 inhibitor ( IC 50 : 0.21 μM). SST0116CL1 free base binds to the ATP binding pocket of Hsp90 , and interferes with Hsp90 chaperone function thus resulting in client protein ( EGFR , CDK4 and AKT ) degradation. SST0116CL1 free base induces degradation of Her2 in BT-474 cell (IC 50 : 0.2 μM). SST0116CL1 free base has antiproliferative activity and inhibits tumor growth. SST0116CL1 free base has antiproliferative activity and inhibits tumor growth. SST0116CL1 free base can be used for the study of leukemia, gastric and ovarian carcinoma.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Akt | Products > Signaling Pathways > HSP | Products > Signaling Pathways > ERK | Products > Signaling Pathways > CDK

Product Information

• Catalog No.: HY-164399A
• CAS No.: 1202920-93-1
• Molecular Formula: C22H30N4O6
• Molecular Weight: 446.50
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source