CCT070535 blocks TCF -dependent transcription at the TCF level, with GI 50 values of 17.6 μM, 11.1 μM, 11.8 μM and 13.4 μM in HT29 ( APC mutant), HCT116 (oncogenic β-catenin ), SW480 ( APC mutant) and SNU475 (Axin mutant) cells, respectively.
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