VUF14480 is a partial agonist of histamine H4 (hH4) receptor -mediated G protein signalling and β-arrestin2 recruitment. VUF14480 binds covalently to hH4 receptor ( pK i : 6.3 for hH4-WT receptor). VUF14480 partially induces hH4 receptor-mediated G protein activation and β-arrestin2 recruitment. VUF14480 can be used in the research of inflammatory diseases.
Products | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Histamine Receptor
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