SMER10

Overview

SMER10 is a small-molecule enhancer that can induce autophagy . SMER10 can increase the number of EGFP-LC3 positive autophagosoms in COS-7 and HeLa cells, promoting the conversion of LC3-I to autophagosome-associated LC3-II . SMER10 can efficiently promote the degradation of autophagy substrates, including the mutant huntingtin protein (EGFP-HDQ74) associated with Huntington's disease and the A53T α-synuclein protein associated with Parkinson's disease. SMER10 exerts neuroprotective effect.

Application

Products | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Atg8/LC3 | Products > Signaling Pathways > Huntingtin | Products > Signaling Pathways > α-synuclein

Product Information

• Catalog No.: HY-165539
• CAS No.: 221238-83-1
• Molecular Formula: C16H17N3O
• Molecular Weight: 267.33
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source