MeS-IMPY is a ligand of β-amyloid plaques . MeS-IMPY shows a high binding affinity to β-amyloid plaques extracted from Alzheimer's disease (AD) human brains or AD brain homogenates compared to IMPY ( K i =7.93 and 8.95 nM, respectively). [ 11 C]MeS-IMPY is a potential radioligand for imaging β-amyloid plaques with positron emission tomography (PET).
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