Tyk2-IN-20 (Example 289) is a potent Tyk2 inhibitor with an IC 50 of <5 nM. Tyk2-IN-20 als inhibits JAK1 , JAK2 , and JAK3 with I IC 50 values of <100 nM. Tyk2-IN-20 can be used for the study of inflammatory diseases.
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