LDHA-IN-9 (Compound 1g) is an inhibitor for LDH-A with an IC 50 of 25 nM. LDHA-IN-9 inhibits the proliferation of DLD-1 cell (GI 50 of 27 μM) through apoptosis induction. LDHA-IN-9 exhibits antitumor activity in mouse model without significant toxicity (25 mg/kg).
Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Lactate Dehydrogenase | Products > Signaling Pathways > Apoptosis
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