BCRP-IN-2 has BCRP inhibitory activity and shows even greater inhibition of BCRP after activation by ultraviolet light. BCRP-IN-2 can be a valuable probe for studying the interactions of quinazolinamine derivatives with BCRP , as it stimulates ATP hydrolysis of the BCRP transport protein, increasing the accumulation of mitoxantrone ( HY-13502 ) in H460/MX20 cells with BCRP overexpression.
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