EZH2-IN-22 (example 92) is a potent EZH2 inhibitor with IC 50 values of <0.00051, <0.00051, 0.00052 µM for EZH2 (Y641N), EZH2 (Y641F), EZH2 (wt), respectively. EZH2-IN-22 shows antiproliferation activity.
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