SIRT6-IN-4

Overview

SIRT6-IN-4 (Compound 10d) is a selective inhibitor for SIRT6 with an IC 50 of 5.68 μM. SIRT6-IN-4 inhibits the proliferation of MCF-7 with an IC 50 of 8.30 μM. SIRT6-IN-4 arrests the cell cycle at G2/M phase, inhibits thecell migration and invasion of MCF-7, and induces apoptosis . SIRT6-IN-4 exhibits antitumor efficacy in mouse models.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Sirtuin | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-170402
• CAS No.: 3075160-74-3
• Molecular Formula: C26H18ClN5O
• Molecular Weight: 451.91
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source