PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual-target inhibitor of PD-L1 and VISTA . PD-L1/VISTA-IN-1 can block the PD-1/PD-L1 interaction ( IC 50 : 0.1492 μM) and the VISTA pathway ( K D : 0.2723 μM), thereby reactivating T cells. PD-L1/VISTA-IN-1 has anti-tumor activity.
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