A2AR modulator-1

Overview

A2AR modulator-1 (Compound 45) is a selective negative allosteric adenosine A 2a receptor ( A 2a R ) modulator with an IC 50 value of 9 nM. A2AR modulator-1 reduces the affinity of endogenous adenosine for the receptor and inhibits cAMP signaling pathway activation. A2AR modulator-1 potently restores pCREB phosphorylation in CD4 + T cells, reversing immunosuppression in the tumor microenvironment, and shows potential to suppress tumor growth and metastasis in triple-negative breast cancer models.

Application

Products | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Adenosine Receptor

Product Information

• Catalog No.: HY-170948
• CAS No.: 3007566-23-3
• Molecular Formula: C23H20N6
• Molecular Weight: 380.45
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source