HDAC3-IN-6 (Compound SC26) is a selective HDAC3 inhibitor with an IC 50 of 53 nM. HDAC3-IN-6 dose-dependently induces the expression of PD-L1 . HDAC3-IN-6 induces more pronounced Apoptosis and production of ROS . HDAC3-IN-6 exhibits high antitumor efficacy against colorectal cancer .
Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > PD-1/PD-L1
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