EGFR-IN-159

Overview

EGFR-IN-159 (compound 12), a dihydropyrimidine, is a potent EGFR inhibitor with an IC 50 value of 29.00 nM. EGFR-IN-159 exhibits dose-dependent inhibition against EGFR and HER2 . EGFR-IN-159 shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC 50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 has no BBB permeation. EGFR-IN-159 shows appreciable anti-cancer activity.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > EGFR

Product Information

• Catalog No.: HY-172621
• CAS No.: 2055746-08-0
• Molecular Formula: C21H23N3O5
• Molecular Weight: 397.42
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source