PDHK1-IN-2 (Compound 24) is an ATP-competitive dual inhibitor of pyruvate dehydrogenase kinases 1/2 ( PDHK1/2 ), with an IC 50 of 0.007 μM for PDHK1 and an IC 50 of 0.015 μM for PDHK2 . PDHK1-IN-2 can regulate immune cell metabolism and correct mitochondrial dysfunction, and is expected to be used in the research of autoimmune diseases, inflammatory diseases, cancers, and other conditions.
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