Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with K i s of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D 2 , D 3 and D 4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).
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