IL4I1-IN-1 (Compound Ex 232 pg 200) is a selective interleukin 4-induced protein 1 ( IL4I1 ) inhibitor with an EC 50 of 2 nM. IL4I1-IN-1 inhibits IL4I1-mediated oxidative deamination of phenylalanine, reducing the production of phenylpyruvate, H 2 O 2 and NH 3 . IL4I1-IN-1 is promising for research of cancers with high IL4I1 expression, such as endometrial carcinoma, ovarian cancer , and triple-negative breast cancer .
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