USP7-IN-18

Overview

USP7-IN-18 is a naphthalene derivative. USP7-IN-18 is a selective USP7 inhibitor ( IC 50 : 130.9 nM), with no or very weak inhibition of the other 8 DUBs including USP47. USP7-IN-18 specifically binds to the catalytic domain of USP7 , blocking its deubiquitinase activity. USP7-IN-18 causes degradation of the oncogenic proteins MDM2 and DNMT1 , and also degrades the novel target PCLAF . USP7-IN-18 activates the p53-p21 pathway. USP7-IN-18 exerts anti-tumor effects in colon cancer animal models and reshapes the tumor immune microenvironment. USP7-IN-18 achieves both direct cytotoxic and immune-synergistic anti-tumor actions.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Deubiquitinase | Products > Signaling Pathways > DNA Methyltransferase | Products > Signaling Pathways > MDM-2/p53

Product Information

• Catalog No.: HY-174301
• CAS No.: 3052223-40-9
• Molecular Formula: C30H28ClN3O3S
• Molecular Weight: 546.08
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source