(2S,3R,4S)-ASX-173

Overview

(2S,3R,4S)-ASX-173 is the (2S,3R,4S)-enantiomer of ASX-173 ( HY-175282 ). ASX-173 is an orally active inhibitor of asparagine synthetase (ASNS) (IC 50 = 0.113 μM, K i = 0.4 nM). ASX-173 enhances the anticancer activity of L-asparaginase (ASNase) ( HY-P1923 ). ASX-173 disrupts nucleotide synthesis and induces leukemia cell cycle arrest, apoptosis and autophagy in leukemia cells in combination with ASNase. ASX-173 slows the growth of OCI-AML2 xenografts in combination with ASNase. ASX-173 is indicated for the study of acute lymphoblastic leukemia, acute myeloid leukemia, colorectal cancer , and other cancers.

Application

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Product Information

• Catalog No.: HY-175282A
• CAS No.: 2748800-07-7
• Molecular Formula: C28H30FN3O3
• Molecular Weight: 475.55
• Purity: 99.29%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (10.51 mM); Clear solution
• Availability: In-stock

Source

Original product source