APY29

Overview

APY29, an ATP-competitive inhibitor, is an allosteric modulator of IRE1α which inhibits IRE1α autophosphorylation by binding to the ATP-binding pocket with IC 50 of 280 nM. APY29 acts as a ligand that allosterically activates IRE1α adjacent RNase domain.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > IRE1

Product Information

• Catalog No.: HY-17537
• CAS No.: 1216665-49-4
• Molecular Formula: C17H16N8
• Molecular Weight: 332.36
• Purity: 98.92%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 5 mg/mL (15.04 mM); Clear solution
• Availability: In-stock

Source

Original product source