Yoda2

CAS No.：3081450-95-2
Grade：99.57%
Formula：C16H9Cl2KN2O2S2
M.W.：435.39
Solvent：≥ 2.5 mg/mL (5.74 mM); Clear solution

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

Yoda2 (KC289), the potassium salt of Yoda1 ( HY-18723 ), is a PIEZO1 agonist with an EC 50 of 150 nM. Yoda2 evokes Ca 2+ elevation and NO-dependent relaxation. Yoda2 induces relaxation in mouse arterial and cavernous tissues. Yoda2 inhibits glucocorticoid-induced osteoclast formation and bone resorptive activity, reverses glucocorticoid-induced bone density loss and architectural deterioration, and does not induce medication-related osteonecrosis of the jaw in mice. Yoda2 can be used for the researches of hypertension and osteoporosis.

Application

Products | Products > Disease Areas > Hypertension | Products > Disease Areas > Osteoporosis | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Mineral Metabolism | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Metabolic Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Piezo Channel | Products > Signaling Pathways > Calcium Channel

Product Information

Catalog No.: HY-175416
CAS No.: 3081450-95-2
Molecular Formula: C16H9Cl2KN2O2S2
Molecular Weight: 435.39
Purity: 99.57%
Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution
Availability: In-stock

Source

Original product source

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