SHP2-IN-44

Overview

SHP2-IN-44 (Compound 26) is an allosteric and orally active SHP2 inhibitor with an IC 50 of 27 ?nM. SHP2-IN-44 also inhibits ERK phosphorylation ( IC 50 of 299 ?nM) without off-target hERG activity. SHP2-IN-44 has a broad-spectrum anticancer activity, such as juvenile myelomonocytic leukemia, neuroblastoma and breast cancer . SHP2-IN-44 can be used for Noonan syndrome, LEOPARD syndrome and cancers research.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > SHP2 | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-175803
• CAS No.: 2818955-47-2
• Molecular Formula: C22H23ClFN7S
• Molecular Weight: 471.98
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source