CS47

Overview

CS47 is a Thioredoxin Reductase 1 ( TRXR1 ) inhibitor and ferroptosis inducer. CS47 binds non-covalently to sites between the FAD and NADPH pockets of TRXR1 . CS47 drives glutathione depletion, lipid reactive oxygen species accumulation, HMOX1 -dependent iron overload, and selective cytotoxicity in lung cancer cells. CS47 can be used for the research of lung cancer .

Application

Products | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > TrxR | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Ferroptosis

Product Information

• Catalog No.: HY-175806
• CAS No.: 1372792-51-2
• Molecular Formula: C21H16AuCl2N2P
• Molecular Weight: 595.21
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source