PD-166285

Overview

PD-166285 is a PKMYT1 inhibitor, with an IC 50 value of 17 nM. PD166285 shows strong antiproliferative effects against CCNE1-amplified OVCAR3 cells ( IC 50 = 0.14 μM) and HCC1569 cells ( IC 50 = 0.21 μM). PD166285 induces apoptosis and arrests CCNE1-amplified HCC1569 cells at the G1/S phase of the cell cycle. PD166285 can be used for the research of PKMYT1-targeted therapies for CCNE1-amplified cancers.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Wee1 | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-175819
• CAS No.: 717094-37-6
• Molecular Formula: C24H23Cl2N5O2
• Molecular Weight: 484.38
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source