CDK9/EZH2-IN-1

Overview

CDK9/EZH2-IN-1 (Compound D16) is a CDK9/EZH2 dual-target inhibitor ( IC 50 : 83.9/108.6 nM). CDK9/EZH2-IN-1 induces apoptosis and DNA double-strand breaks ( DSBs ). CDK9/EZH2-IN-1 inhibits the proliferation activity of MKN45, MDA-MB-453 and SW620 cancer cells ( IC 50 values are 136.3, 171.3 and 315.7 nM, respectively).

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Histone Methyltransferase

Product Information

• Catalog No.: HY-176165
• CAS No.: 3081246-18-3
• Molecular Formula: C47H59N11O4S2
• Molecular Weight: 906.17
• Purity: 99.08%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.76 mM); Clear solution
• Availability: In-stock

Source

Original product source