MAO-B-IN-45

Overview

MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B . MAO-B-IN-45 shows selectivity towards MAO-B with an IC 50 of 87.47 nM and selectivity exceeding 229-fold for MAO-B over MAO-A . MAO-B-IN-45 has excellent antiferroptosis activity through modulation of the iron metabolic pathway and GSH-GPX4 axis in vitro. MAO-B-IN-45 improves cognitive and behavioral impairments in 3×Tg (APP/Tau/Ps1) AD mouse and significantly reduced the levels of ferritin heavy chain 1 (FTH1), APP, and Tau phosphorylation (p-Tau) proteins in the brain.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Tau Protein | Products > Signaling Pathways > Amyloid-β | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Monoamine Oxidase | Products > Signaling Pathways > Glutathione Peroxidase

Product Information

• Catalog No.: HY-176271
• CAS No.: 3069915-36-9
• Molecular Formula: C17H14ClNO3
• Molecular Weight: 315.75
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source