VU6031545 is a potent mGlu 5 negative allosteric modulator with an IC 50 of 15 nM. VU6031545 has excellent brain penetrant and oral bioavailability in rats.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > mGluR
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