M119 (NSC 119910) is a selective Gβγ -subunit inhibitor. M119 selectively potentiates μ-opioid -dependent antinociception. M119 inhibits μ-receptor-dependent phospholipase ( PLC ) activation. M119 can enhance opioid analgesia and attenuate its acute tolerance and dependence in mice. M119 can be used for pain research.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Pain | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Phospholipase | Products > Signaling Pathways > Opioid Receptor
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