MEK-IN-7 (compound WX086) is potent, orally active and selective MEK inhibitor ( MEK1 IC 50 = 29.62 nM). MEK-IN-7 inhibits HT29 and A375 cell proliferation with IC 50 s of 0.62 and 0.40 nM. MEK-IN-7 inhibits tumor growth in a HL-29 xenograft mouse model. MEK-IN-7 can be used for melanoma and colon cancer research.
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