FLT3-IN-34

Overview

FLT3-IN-34 is a FLT3 inhibitor, with an IC 50 value of 1.4 nM. FLT3-IN-34 blocks the phosphorylation of FLT3 and its downstream signaling molecules AKT and ERK1/2 . FLT3-IN-34 induces concentration-dependent G0/G1 phase arrest and mild apoptosis in FLT3 -ITD-positive MV4-11 cells. FLT3-IN-34 shows potent anti-proliferative activity against FLT3-ITD-positive MV4-11 cells ( IC 50 = 14.95 nM) and MOLM-13 ( IC 50 = 18.5 nM). FLT3-IN-34 can be used for the study of FLT3 -positive acute myeloid leukemia (AML).

Application

Products | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > FLT3 | Products > Signaling Pathways > ERK | Products > Signaling Pathways > Akt

Product Information

• Catalog No.: HY-178020
• CAS No.: 3020729-11-4
• Molecular Formula: C23H23N5O3
• Molecular Weight: 417.46
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source