LMDP10

Overview

LMDP10 is an orally active 3-amino quinazoline derivative with Keap1-Nrf2 pathway activation activity. LMDP10 binds to Keap1 to inhibit Keap1-Nrf2 interaction, thereby activating the Nrf2 pathway. LMDP10 elevates Nrf2 , SOD , and GSH levels, reduces MDA and TNF-α levels, attenuates neurodegeneration, and improves memory function in Alzheimer’s disease (AD) rats. LMDP10 can be used for the study of AD.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Others | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > Drug Derivative

Product Information

• Catalog No.: HY-178054
• CAS No.: 2760446-25-9
• Molecular Formula: C29H21FN4O3
• Molecular Weight: 492.50
• Purity: 99.91%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 1.67 mg/mL (3.39 mM); Clear solution
• Availability: In-stock

Source

Original product source